Association of ceftriaxone with fatal outcome when administered intravenously with calcium-containing solutions

From Health Canada:
There is a risk of precipitation when ceftriaxone and calcium are administered concurrently via intravenous route.

Cases of fatal reactions with ceftriaxone-calcium precipitates in lung and kidneys have been described in neonates and infants (ref 1-4). In some cases the infusion lines and the times of administration of ceftriaxone and calcium-containing solutions differed.

Although there are no reports to date of intravascular precipitations in patients, other than neonates, treated with ceftriaxone and calcium-containing solutions, the theoretical possibility exists for an interaction between ceftriaxone and calcium-containing solutions in patients other than neonates. ...more