From the Globe and Mail:
Canada risks losing out on the next wave of lucrative pharmaceutical investment and jobs unless it matches tougher patent protection for drug makers in the U.S. and Europe, says a new report for the Canadian Chamber of Commerce.
Canada has fallen behind many other leading advanced countries in patent protection, impairing the country’s investment climate, concludes the report by the Canadian Intellectual Property Council, an arm of the Chamber composed of drug makers, consumer product companies, technology companies and lawyers.
The report, being released Wednesday, urges Ottawa to give patented drug makers up to five years of “restored” patent life to offset regulatory delays, exclusive use of drug trial data for an extra two years plus new legal tools to fight patent challenges launched by generic manufacturers.
“The world has continued to move on. We haven’t,” Chamber president Perrin Beatty said in an interview.
Any move to strengthen patent protection would be extremely contentious because it would mean higher prices for many new drugs, raising costs for consumers, insurers and provincial health plans. And Canada’s generic drug industry, along with several provincial governments would likely fight them vigorously. ...more
Wednesday, January 19, 2011
Use of antidepressant to treat hot flashes raises concern
From the Montreal Gazette:
First came the fallout from hormones. Now alarms are being raised about a new treatment for menopause: mood-altering drugs.
With enthusiasm for hormones cooling, doctors are increasingly experimenting with antidepressants for hot flashes.
In the latest study published this week, researchers report that women given escitalopram, or Cipralex, a drug used for major depressive disorders, had fewer hot flashes after eight weeks of treatment.
Overall, 55 per cent of the women in the drug group versus 36 per cent taking a placebo reported a decrease of at least 50 per cent in "hot flash frequency," according to the study, published in the Journal of the American Medical Association.
Although the drug is only approved for anxiety and major depressive disorders, women who were not "clinically anxious or depressed" responded to the drug, the researchers said. Furthermore, "response was rapid, with significantly greater improvement among women taking escitalopram than placebo after one week of treatment." ...more
First came the fallout from hormones. Now alarms are being raised about a new treatment for menopause: mood-altering drugs.
With enthusiasm for hormones cooling, doctors are increasingly experimenting with antidepressants for hot flashes.
In the latest study published this week, researchers report that women given escitalopram, or Cipralex, a drug used for major depressive disorders, had fewer hot flashes after eight weeks of treatment.
Overall, 55 per cent of the women in the drug group versus 36 per cent taking a placebo reported a decrease of at least 50 per cent in "hot flash frequency," according to the study, published in the Journal of the American Medical Association.
Although the drug is only approved for anxiety and major depressive disorders, women who were not "clinically anxious or depressed" responded to the drug, the researchers said. Furthermore, "response was rapid, with significantly greater improvement among women taking escitalopram than placebo after one week of treatment." ...more
Rate of statin prescriptions not backed by solid proof: Study
From the Montreal Gazette:
There's no evidence to support the widespread prescribing of cholesterol-lowering pills for people at low risk of heart attacks and stroke, a new study concludes.
Millions of Canadians take the cholesterol-reducers known as statins. An estimated 30.3 million prescriptions for the drugs were filled in Canada last year, according to IMS Brogan, a prescription-drug tracking firm.
For people with a history of cardiovascular disease, statins have been shown to save lives.
"But people are now taking statins who don't have any previous evidence of heart attack or stroke," said co-author Dr. Shah Ebrahim, a professor of public health at the London School of Hygiene and Tropical Medicine in England. ...more
There's no evidence to support the widespread prescribing of cholesterol-lowering pills for people at low risk of heart attacks and stroke, a new study concludes.
Millions of Canadians take the cholesterol-reducers known as statins. An estimated 30.3 million prescriptions for the drugs were filled in Canada last year, according to IMS Brogan, a prescription-drug tracking firm.
For people with a history of cardiovascular disease, statins have been shown to save lives.
"But people are now taking statins who don't have any previous evidence of heart attack or stroke," said co-author Dr. Shah Ebrahim, a professor of public health at the London School of Hygiene and Tropical Medicine in England. ...more
Tuesday, January 18, 2011
Truro pharmacist disciplined for second time
From CBC News:
The Nova Scotia College of Pharmacists has disciplined a Truro pharmacist for professional misconduct a second time.
In July, a professional investigation committee found Michael McKeigan lied to a patient and failed to transfer prescription information to another pharmacy when requested.
McKeigan was also found to have impersonated another pharmacist on the phone and misled the professional investigation committee.
This is the second time McKeigan has faced professional discipline.
In 2008, he was censured for defrauding a Walmart pharmacy where he worked. ...more
The Nova Scotia College of Pharmacists has disciplined a Truro pharmacist for professional misconduct a second time.
In July, a professional investigation committee found Michael McKeigan lied to a patient and failed to transfer prescription information to another pharmacy when requested.
McKeigan was also found to have impersonated another pharmacist on the phone and misled the professional investigation committee.
This is the second time McKeigan has faced professional discipline.
In 2008, he was censured for defrauding a Walmart pharmacy where he worked. ...more
Avoid brand-name painkiller, pharmacists told
From CBC News:
Specialists with Nova Scotia's Prescription Monitoring Program are telling pharmacists to use a generic painkiller that is more difficult to abuse than its name brand version.
Dr. Peter MacDougall, an anesthetist and pain management specialist for the Nova Scotia Prescription Monitoring Program, says Dilaudid — the brand-name form of hydromorphone — can trigger a powerful high when it's injected with a needle.
"Dilaudid is a much easier drug to make injectable," he said. "It's easier to crush and to dissolve in a liquid, usually water. The hard-core addicts can then inject that." ...more
Specialists with Nova Scotia's Prescription Monitoring Program are telling pharmacists to use a generic painkiller that is more difficult to abuse than its name brand version.
Dr. Peter MacDougall, an anesthetist and pain management specialist for the Nova Scotia Prescription Monitoring Program, says Dilaudid — the brand-name form of hydromorphone — can trigger a powerful high when it's injected with a needle.
"Dilaudid is a much easier drug to make injectable," he said. "It's easier to crush and to dissolve in a liquid, usually water. The hard-core addicts can then inject that." ...more
Sale of Katz Group 'might be approaching': analyst
From the Edmonton Journal:
Amid the shakeout in drug regulation across Canada, a CIBC World Markets analyst is theorizing that Edmonton-based drugstore chain Katz Group Canada Ltd. may be for sale and that Jean Coutu Group Inc. would be a logical buyer.
"We have speculated for quite some time that Katz Group could be for sale, and would not be surprised if U.S.-based players, both wholesale and retail, are already kicking the tires," analyst Perry Caicco writes in a research note on Jean Coutu published Jan. 9.
"With reduced profitability and remaining uncertainty about drug reforms in certain provinces, most notably Alberta, the time for a Katz Group deal might be approaching."
Jean Coutu and the Katz Group declined to comment Tuesday.
Katz is one of Canada's largest privately held companies, with more than 1,800 drugstore outlets across the country under the banners Rexall, PharmaPlus, Guardian and IDA. It is controlled by Edmonton businessman Daryl Katz and his family. Katz also owns the Edmonton Oilers. ...more
Amid the shakeout in drug regulation across Canada, a CIBC World Markets analyst is theorizing that Edmonton-based drugstore chain Katz Group Canada Ltd. may be for sale and that Jean Coutu Group Inc. would be a logical buyer.
"We have speculated for quite some time that Katz Group could be for sale, and would not be surprised if U.S.-based players, both wholesale and retail, are already kicking the tires," analyst Perry Caicco writes in a research note on Jean Coutu published Jan. 9.
"With reduced profitability and remaining uncertainty about drug reforms in certain provinces, most notably Alberta, the time for a Katz Group deal might be approaching."
Jean Coutu and the Katz Group declined to comment Tuesday.
Katz is one of Canada's largest privately held companies, with more than 1,800 drugstore outlets across the country under the banners Rexall, PharmaPlus, Guardian and IDA. It is controlled by Edmonton businessman Daryl Katz and his family. Katz also owns the Edmonton Oilers. ...more
Don't exceed top dose of acetaminophen when taking painkillers: Health Canada
From the Winnipeg Free Press:
As the United States announced Thursday that it would cap the amount of acetaminophen allowed in prescription painkillers, Health Canada issued a statement saying that it continues to review current and emerging safety evidence.
The U.S. Food and Drug Administration said the limit would be 325 milligrams of acetaminophen per capsule in painkillers such as Vicodin and Percocet.
The FDA cited the risk of liver injury, which mainly occurs when patients take multiple products containing acetaminophen at one time and exceed the current maximum dose of 4,000 milligrams within a 24-hour period.
"Health Canada continues to review emerging and available safety evidence, including that used by the FDA to reach its decision and will determine if any new action may be needed to protect health and safety," the agency said in its statement Thursday. ...more
As the United States announced Thursday that it would cap the amount of acetaminophen allowed in prescription painkillers, Health Canada issued a statement saying that it continues to review current and emerging safety evidence.
The U.S. Food and Drug Administration said the limit would be 325 milligrams of acetaminophen per capsule in painkillers such as Vicodin and Percocet.
The FDA cited the risk of liver injury, which mainly occurs when patients take multiple products containing acetaminophen at one time and exceed the current maximum dose of 4,000 milligrams within a 24-hour period.
"Health Canada continues to review emerging and available safety evidence, including that used by the FDA to reach its decision and will determine if any new action may be needed to protect health and safety," the agency said in its statement Thursday. ...more
Researchers warn of dangerous drug reactions
From the Vancouver Sun:
Tens of thousands of Canadians are being exposed to a potentially dangerous drug mix involving two of the most widely prescribed drugs in Canada — a drug interaction that can cause plummeting blood pressure, or shock, researchers are warning.
Combining calcium-channel blockers — drugs used to treat high blood pressure and angina — with two commonly used antibiotics can increase the risk of abnormally low blood pressure up to six fold, according to a study published Monday in Canada's top medical journal.
The antibiotics — erythromycin and clarithromycin — belong to the drug class known as macrolide antibiotics, the most widely used antibiotics on the market. An estimated 2.9 million prescriptions for erythromycin and clarithromycin were filled by Canadian retail drug stores in 2009, according prescription drug-tracking firm IMS Brogan.
Calcium-channel blockers, meanwhile, are among the top selling drugs in Canada. Nearly 16 million prescriptions for the drugs were dispensed in 2009. They are the ninth most commonly prescribed drug class in the U.S., with almost 90 million prescriptions filled in 2008. ...more
Tens of thousands of Canadians are being exposed to a potentially dangerous drug mix involving two of the most widely prescribed drugs in Canada — a drug interaction that can cause plummeting blood pressure, or shock, researchers are warning.
Combining calcium-channel blockers — drugs used to treat high blood pressure and angina — with two commonly used antibiotics can increase the risk of abnormally low blood pressure up to six fold, according to a study published Monday in Canada's top medical journal.
The antibiotics — erythromycin and clarithromycin — belong to the drug class known as macrolide antibiotics, the most widely used antibiotics on the market. An estimated 2.9 million prescriptions for erythromycin and clarithromycin were filled by Canadian retail drug stores in 2009, according prescription drug-tracking firm IMS Brogan.
Calcium-channel blockers, meanwhile, are among the top selling drugs in Canada. Nearly 16 million prescriptions for the drugs were dispensed in 2009. They are the ninth most commonly prescribed drug class in the U.S., with almost 90 million prescriptions filled in 2008. ...more
Heart drug Multaq to be monitored in Canada
From CBC News:
The heart drug Multaq continues to be approved for use in Canada, but Health Canada says reports of its connection to liver damage will be reviewed.
On Friday, the U.S. Food and Drug Administration added new warnings to the label of the Sanofi-Aventis drug after several reports that patients suffered liver damage.
Multaq was approved in July 2009 to treat atrial flutter and atrial fibrillation — irregular heart rhythms that can reduce blood flow and lead to stroke.
Liver toxicity is among the most common drug-related side-effects in a number of medication classes.
Health Canada says that in Canada the drug is not to be used by patients with severe liver problems. It says that should new safety information be identified, it will take appropriate action — including keeping health-care professionals and other Canadians informed.
Up to Oct. 31, Health Canada received 40 adverse reaction reports representing 37 cases (three of the reports were duplicates) with the suspect product being Multaq. It says none of these reports were related to liver damage. ...more
The heart drug Multaq continues to be approved for use in Canada, but Health Canada says reports of its connection to liver damage will be reviewed.
On Friday, the U.S. Food and Drug Administration added new warnings to the label of the Sanofi-Aventis drug after several reports that patients suffered liver damage.
Multaq was approved in July 2009 to treat atrial flutter and atrial fibrillation — irregular heart rhythms that can reduce blood flow and lead to stroke.
Liver toxicity is among the most common drug-related side-effects in a number of medication classes.
Health Canada says that in Canada the drug is not to be used by patients with severe liver problems. It says that should new safety information be identified, it will take appropriate action — including keeping health-care professionals and other Canadians informed.
Up to Oct. 31, Health Canada received 40 adverse reaction reports representing 37 cases (three of the reports were duplicates) with the suspect product being Multaq. It says none of these reports were related to liver damage. ...more
Sunday, January 16, 2011
Some cancer patients trying vitamin-C treatment
From the Vancouver Sun:
When Sandra Quattrin was diagnosed with breast cancer nine months ago, she choose to treat it with vitamin-C infusions against the advice of her doctor, who prescribed chemotherapy.
The 44-year-old is one of several cancer patients receiving vitamin C intravenously at the Canadian Clinic for Integrative Medicine in Ontario, run by naturopathic doctor Denis Marier and partnered with a local hospice in Windsor.
The therapy is based on research that suggests vitamin C, or ascorbic acid, can be toxic to cancer cells when administered in high doses. First introduced about 30 years ago, the idea that vitamin C can successfully treat cancer is either dismissed outright or hotly debated among oncologists and scientists.
When Marier opened his clinic two years ago, "There was a lot of push back" from oncologists at the Windsor Regional Cancer Centre, he said.
"But they're starting to come around. I'm not here to say I've got a different way and my way is better. ...more
When Sandra Quattrin was diagnosed with breast cancer nine months ago, she choose to treat it with vitamin-C infusions against the advice of her doctor, who prescribed chemotherapy.
The 44-year-old is one of several cancer patients receiving vitamin C intravenously at the Canadian Clinic for Integrative Medicine in Ontario, run by naturopathic doctor Denis Marier and partnered with a local hospice in Windsor.
The therapy is based on research that suggests vitamin C, or ascorbic acid, can be toxic to cancer cells when administered in high doses. First introduced about 30 years ago, the idea that vitamin C can successfully treat cancer is either dismissed outright or hotly debated among oncologists and scientists.
When Marier opened his clinic two years ago, "There was a lot of push back" from oncologists at the Windsor Regional Cancer Centre, he said.
"But they're starting to come around. I'm not here to say I've got a different way and my way is better. ...more
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