Asthma drug linked to suicide attempts, thoughts of self-harm

From Canada.com:
The side-effects of a popular asthma medication that has been sold in Canada for 12 years has been linked to suicide attempts and thoughts of suicide, as well as feelings of depression and hostility.

The July 2009 issue of the Canadian Adverse Reaction Newsletter from Health Canada cites montelukast sodium — which has been marketed in Canada since 1997 as Singulair — as having several connections to the alarming reactions.

Between its introduction to the Canadian market and Jan. 31, 2009, Singulair has been linked to two suicide attempts in Canada and 11 cases where users had thoughts of suicide or self-harm. In 29 other cases, 14 of which were labelled as "serious adverse reactions," those affected suffered from depression, hostility or other psychosis. No deaths have been linked to the drug's side-effects. ...more

'Don't stop asthma meds in pregnancy'

From IrishHealth.com:
Pregnant women who have asthma run a greater risk of giving birth prematurely if they stop taking their asthma medication, the results of a new study indicate.

According to researchers at the University of Montreal in Canada, ‘many pregnant women cease taking their asthma medication to protect the health of their child. However, they don't know that unchecked asthma can cause greater harm to the child than the medication’.

The researchers also pointed out that there is no link between taking asthma medication, such as Ventolin, and any congenital birth defect.

The study involved 13,000 pregnant women who consulted a doctor about asthma between 1990 and 2002. The Canadian team analysed the medication used by these women and their rate of admission to hospital following visits to A&E.

It found that those who suspended their asthma treatment during pregnancy were more likely to give birth prematurely. The probability of suffering from hypertension (high blood pressure) during pregnancy also increased among those who stopped taking their medication. ...more

Cases of asthma in Canada may be overdiagnosed by 30 per cent: study

From the Canadian Press:
Almost a third of adult Canadians diagnosed with asthma and taking medications to treat their wheezing, coughing and shortness of breath may not actually have the allergic respiratory condition at all, researchers say.

In a study of about 500 adults who had previously been told they have asthma, airway-function and other tests showed that about 30 per cent did not in fact have the disease, suggesting that asthma may be significantly overdiagnosed in Canada.

"What we think is happening ... is that if patients come to a physician complaining of shortness of breath or cough or wheeze, oftentimes the physician will assume that the diagnosis is asthma, and based on the patient's history and complaints prescribe medicines to treat asthma," lead investigator Dr. Shawn Aaron said from Ottawa.

"And what they won't do is order the appropriate diagnostic test to confirm asthma."

Aaron, head of respiratory medicine at Ottawa Hospital and the University of Ottawa, said a doctor's suspicion that a patient has asthma should be followed up by confirmatory tests, including spirometry. ...more

Asthma drugs help to prevent birth defects

From the Globe and Mail:
Women who have an asthma attack during the first three months of pregnancy put their babies at a greater risk of birth defects than asthmatic mothers who did not have a flare-up during that period, a new Canadian study shows.

The research, published in next month's issue of the Journal of Allergy and Clinical Immunology, found that women who had uncontrolled asthma during this crucial period in fetal development were 48 per cent more likely to have a baby with at least one birth defect compared with those who were taking their medication.

"I hope it will encourage women to continue their treatment during pregnancy. This gives some evidence that stopping your treatment and then being more at risk of having an asthma attack puts your baby at risk of having a congenital malformation," Lucie Blais, an associate professor in pharmacy at the University of Montreal and lead author of the study, said in an interview yesterday. ...more

Antibiotic use before first birthday linked to asthma later in childhood: study

From the Montreal Gazette:
Children treated with antibiotics in their first year of life appear to have a significantly higher risk of developing asthma compared with babies not given the drugs, a Canadian study suggests.

The study, published in the June issue of the journal Chest, found that the risk for asthma doubled in tots receiving antibiotics for non-respiratory infections, as well as for youngsters who received multiple antibiotic courses and who did not live with a family dog before their first birthday.

"Antibiotics are prescribed mostly for respiratory tract infections, yet respiratory symptoms can be a sign of future asthma," said lead author Anita Kozyrskyj of the University of Manitoba. "This may make it difficult to attribute antibiotic use to asthma development." ...more

Procedure treats asthma without drugs

This isn't really a pharmacy story, but I thought it was an interesting new treatment.

From the Globe and Mail:
Asthma can be treated, safely and effectively, with a procedure that uses electromagnetic energy to alter problematic muscles in the airways, according to promising new Canadian research.

The procedure, known as bronchial thermoplasty, does not cure asthma, nor will it eliminate the ubiquitous inhaler, but it reduces symptoms and lessens the need for drugs to treat the condition.

It is the first non-drug treatment for the common breathing disorder, good news for sufferers who have trouble controlling their symptoms with traditional anti-inflammatory drugs such as steroids. ...more