Important Safety Information on Concomitant Use of PAXIL or PAXIL CR and pimozide (Orap)

From Health Canada:
The concomitant use of PAXIL® or PAXIL CR™ and pimozide (Orap®) is contraindicated as paroxetine has been shown to increase plasma pimozide levels. Elevation of pimozide blood concentration may result in QT interval prolongation and severe arrhythmias including Torsade de Pointes.
...more