Showing posts with label ceftriaxone. Show all posts
Showing posts with label ceftriaxone. Show all posts

Wednesday, August 06, 2008

Association of ceftriaxone with fatal outcome when administered intravenously with calcium-containing solutions

From Health Canada:
There is a risk of precipitation when ceftriaxone and calcium are administered concurrently via intravenous route.

Cases of fatal reactions with ceftriaxone-calcium precipitates in lung and kidneys have been described in neonates and infants (ref 1-4). In some cases the infusion lines and the times of administration of ceftriaxone and calcium-containing solutions differed.

Although there are no reports to date of intravascular precipitations in patients, other than neonates, treated with ceftriaxone and calcium-containing solutions, the theoretical possibility exists for an interaction between ceftriaxone and calcium-containing solutions in patients other than neonates. ...more